Lead Investigator • Co-Director of Bioinformatics • Division of Cancer Biology
Comprehensive Cancer Center of the University of Puerto Rico
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Adjunct Associate Professor • Department of Genetics
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Hector L. Franco, Ph.D.
Principal Investigator
Dr. Franco has an enduring interest in understanding how the human genome works and how genes become deregulated in cancer. Using an interdisciplinary approach that combines high-throughput genomics and genetic engineering techniques, the Franco lab works to uncover the underlying molecular mechanisms that control gene expression. In addition, Dr. Franco aims to understand how cancer cells rewire basic mechanisms of gene expression to drive tumor biology and response to therapy with the goal of highlighting novel avenues for therapeutic interventions.
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Dr. Franco completed a bachelors degree in Molecular Biology at Florida Tech while on an athletic scholarship as member of the university's soccer team. He returned home to complete his Ph.D. in Biochemistry at the University of Puerto Rico School of Medicine. Dr. Franco went on to complete his postdoctoral training in Cancer Genomics at UT Southwestern Medical Center in Dallas in the laboratory of Dr. W. Lee Kraus. His postdoctoral work was funded by the American Cancer Society and a K99/R00 grant from the NCI. The Franco lab was founded in 2017 in the Lineberger Cancer Center at UNC Chapel Hill. The lab published several important papers in the fields of cancer genetics, gene expression, and single-cell genomics and has been funded by the Dept. of Defense, The V-Foundation for Cancer Research, Susan G Komen, and the National Cancer Institute. Dr. Franco was granted promotion to Associate Profesor with Tenure at UNC Chapel Hill in 2023.
Rosemary Plagens, Ph.D.
Postdoc
plagens@med.unc.edu
Rosemary obtained her PhD in Cell and Molecular Biology from Florida Tech where she focused on the effects of chronic stress on gene expression. In the Franco lab, she is funded by the UNC Cancer Epigenetics Training Program and will be using the CRISPR toolkit to study gene expression in breast cancer.
![IMG_8463(1)[74].jpg](https://static.wixstatic.com/media/810835_edf2da021c534ad2af5805e3ba804c4c~mv2.jpg/v1/crop/x_33,y_177,w_1376,h_1468/fill/w_232,h_248,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/IMG_8463(1)%5B74%5D.jpg)
Matthew J. Regner
Bioinformatics
Graduate Student
regnerm@live.unc.edu
Matt is a graduate student in the Bioinformatics and Computational Biology graduate program. He joined the lab in 2020 and is working on single-cell genomics data analysis. He is specifically interested in statistical approaches to integrate single-cell RNA-seq data with single-cell ATAC-seq data in human tumors.
Alec V. Lobanov
Bioinformatics
Graduate Student
lobanov@email.unc.edu
Alec is a graduate student in the Bioinformatics and Computational Biology graduate program and is co-mentored by Dr. Chuck Perou. He joined the lab in 2023 and is working on single-cell genomics data analysis. He is specifically interested in determining the enhancer/regulatory logic of cancer cells using various genomic tools. Alec obtained his bachelor's degree in biology and computer science at Boston College. Outside the lab Alec enjoys the outdoors, including playing soccer, cycling, and running the Boston Marathon!
Haiyang(Harry) Wang
Pathology and Cell Biology
Graduate Student
haiyangw@email.unc.edu
Harry joined the Franco lab in 2023 and is co-mentored by Dr. Brian Miller. He is a graduate student in the Pharmacology curriculum. He graduated from Henan Agricultural University in 2018 with a B.E. in Bioengineering and then completed his master's degree in Biotechnology at Georgetown University in 2019. His project is related to the epigenetic basis of macrophage cell states in cancer. He enjoys hiking, running, and trying new food.
LAB ALUMNI
LAB ALUMNI
Michael W. Lewis, Ph.D.
Dr. Lewis successfully completed his postdoctoral training in the Franco lab and has been hired as a Scientist II at Life Edit Inc.
LAB ALUMNI
Michael R. Kelly
Michael Kelly, successfully completed his Ph.D. in Bioinfirmatics and Computational Biology in the Franco Lab and was swiftly recruited as a Bioinformatics Scientist by Tempus Inc.
LAB ALUMNI
Shen Li, Ph.D.
Shen Li was a postdoctoral fellow in the Franco lab working on projects related to genetic engineering of FOXA1 in breast cancer. He will continue his training at Fox Chase Cancer Center in Philadelphia.
LAB ALUMNI
Caitlin King, MS
Caitlin was a lab tech in the Franco lab and collaborated on many CRISPR based projects. She is currently a research associate in Karen Mohlke at UNC
LAB ALUMNI
Kamila Wisniewska
Kamila was a long time lab manager and technician for the Franco lab. During her time in the lab she trained in various coding languages and data analysis techniques that propelled her into a career as a data analysis in i
LAB ALUMNI
Raul Mendez-Giraldez, Ph.D.
Raul was a computational biologist in the Franco Lab. He helped analyze data for various projects in the lab, including the single cell genomics projects. Raul is currently a bioinformatician at the NIH.
LAB ALUMNI
Colby A. Tubbs
Colby was a Franco lab research tech working on the generation of transcription factor mutants using CRISPR/Cas9 methodologies in breast cancer. He is currently a graduate student at Vanderbilt University.
LAB ALUMNI
Gabriela Ramirez Renta
Gabriela completed her summer internship in 2019 as part of the UNC Summer Of Learning And Research SOLAR program. She is a senior undergraduate at the University of Puerto Rico.
LAB ALUMNI
Roberto Herrera Del Valle
Roberto was a summer intern in the Franco Lab. He is currently a graduate student at the University of Virginia.