Uncovering the mechanisms of gene expression in cancer through genomics and computational biology
The Franco Lab has an enduring interest in understanding how the human genome works and how genes become deregulated in cancer. Using an interdisciplinary approach, we are working to uncover the underlying molecular mechanisms that control gene expression and the ways in which the epigenome and non-coding RNAs influence these processes.
By combining state-of-the-art molecular and cellular techniques with powerful genomic and computational approaches, we aim to better understand cancer biology and provide novel avenues for therapeutic interventions.
Roles of non-encoding enhancer RNAs in gene regulation
Crosstalk between pro-inflammatory & endocrine signaling in hormone-dependent cancers