Principal Investigator

 Hector L. Franco, Ph.D. 

Assistant Professor 

UNC Lineberger Cancer Center

Department of Genetics

UNC Chapel Hill School of Medicine

hfranco@med.unc.edu

Dr. Franco has a long standing interest in gene regulation, particularly as it pertains to cancer. He is interested in learning how the human genome is organized and how regulatory information is encoded into our DNA so that we can better understand what goes wrong in diseases such as cancer. 

Dr. Franco was born and raised in Cataño, Puerto Rico. He completed a bachelors degree in Molecular Biology at Florida Institute of Technology and was awarded an athletic scholarship to be a member of the university's soccer team. He returned home to complete his Ph.D. in Biochemistry and Genetics at the University of Puerto Rico School of Medicine under the tutelage of Dr. Carmen Cadilla. For his thesis, Dr. Franco studied the roles of the Twist family of transcription factors in developmental diseases. Following his Ph.D., Dr. Franco completed his postdoctoral training in Genomics in the laboratory of Dr. W. Lee Kraus at UT Southwestern Medical Center. There, he gained expertise in next-generation sequencing methodologies combined with computational analyses to study mechanisms of gene expression in cancer. His postdoctoral work was funded by the American Cancer Society and a K99/R00 grant from the National Cancer Institute.   

 

Administrative Associate

Daniela Miteva

dmiteva@email.unc.edu

Daniela is an integral member of the Franco lab and facilitates the administrative and logistical operations of the lab. She also contributes extensively to the broader research mission of the Lineberger Comprehensive Cancer Center.  

 

Lab Manager & Technician

Kamila Wisniewska

kamila@med.unc.edu

Kamila is in charge of the day to day operations of the lab and handles mouse related projects. In addition, Kamila leads her own project related to the genomic mechanisms of a novel transcription factor in triple negative breast cancer. Kamila obtained her B.S. in Molecular Biology from Loyola University Chicago. In her free time she enjoys training for powerlifting competitions, traveling, and finding new places to hike.  

 

Shen Li, Ph.D.

shen.li@med.unc.edu

Shen obtained his PhD in Molecular Biology at the University of South Carolina where he focused on mechanisms of homologous recombination. In the Franco Lab, he is using his expertise in genetic engineering to generate mutations in pioneer transcription factors, using CRISPR/Cas9 methodologies, to study their functions in cancer. In his spare time he enjoys hiking, jogging and watching thrilling movies. 

 

Postdoctoral Fellow

Postdoctoral Fellow

Michael W. Lewis, Ph.D.

lewismw@email.unc.edu

Mike obtained his PhD in Medical Sciences Genetics at the University of Florida College of Medicine where he focused on mechanisms of epigenetic imprinting during mammalian development. In the Franco Lab, he is currently funded by the NIH-NRSA Cancer Epigenetics Training Program at UNC, and leads projects related to non-coding enhancer RNAs and their roles in gene regulation in cancer. 

 

 

Computational Biologist

Raul Mendez-Giraldez, Ph.D.

rmendez@email.unc.edu

Raul obtained his Master's in Biotechnology at the University of Barcelona and a PhD in Bioinformatics at the Université Libre de Bruxelles, in Brussels, Belgium. In the Franco Lab, he uses his expertise in bioinformatics to study genome biology, gene regulation, epigentics and molecular modeling. He performs analysis on novel NGS data sets and collaborates with the other team members to develop new concepts and programs for data collection and analysis.  

 

 

Graduate Student

Michael R. Kelly

mkelly95@live.unc.edu

Mike is a graduate student in the Bioinformatics and Computational Biology Graduate Program.  He joined the Franco Lab in May and is  working on computational methods to identify regulatory regions throughout the cancer genome. In addition, he is interested in defining enhancer-target-gene relationships and the role of copy number alterations in non-coding regions of the genome. 

 

 

Lab Technician 

Colby A. Tubbs

ctubbs@live.unc.edu

Colby recently graduated from UNC Chapel Hill with a degree in Biology. He is working on the generation of transcription factor mutants using CRISPR/Cas9 methodologies in breast cancer. 

 

 

Lab Alumni 

Gabriela Ramirez Renta

Gabriela completed her summer internship in 2019 as part of the UNC Summer Of Learning And Research SOLAR program. She is a senior undergraduate at the University of Puerto Rico. 

Emma R. Hinkle

Emma is a graduate student in the Genetics and Molecular Biology Graduate program at UNC. During her rotation in the Franco lab,  she worked on the molecular and genomic crosstalk of endocrine and inflammatory signaling in ovarian cancer.  

Angana Mukherjee

Angana is a graduate student in the Pathobiology and Translational Science program at UNC. During her rotation in the Franco lab, she worked on CRISPR approaches for endogenous tagging of transcription factors.  

 

Roberto Herrera Del Valle

Roberto was a summer intern in the Franco Lab. He is currently an undergraduate student at the University of Puerto Rico at Cayey majoring in Biology.  

 

 

thefrancolab.org

© 2019 This website reflects only the views of the author and is not a publication of The University of North Carolina, which bears no responsibility for its content.

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